Moderate to Severe Rheumatoid Arthritis (RA)
Moderate to Severe Polyarticular Juvenile Idiopathic Arthritis (JIA)

See how ORENCIA® (abatacept) helped these RA patients get back to doing everyday things.

Melissa's "Oh, Yes I Can!"™ moment was the day she finally turned the shower faucet without pain. For Ray, it was no longer feeling like a "sideline dad." Whether at home or work, many patients taking ORENCIA have gotten back to doing many of the everyday things they'd lost to rheumatoid arthritis (RA). Now watch these inspiring videos of their personal stories.

Can you see your story in these ORENCIA patient videos?

Some of these ORENCIA patients may even share many of your struggles. But now, with ORENCIA, things are different. Watch them talk about the challenges they faced and the everyday successes they've found.

Safety Information About ORENCIA® (abatacept)

ORENCIA can cause serious side effects including serious infections and allergic reactions. The more common side effects with ORENCIA in both adults and children are headache, upper respiratory tract infection, sore throat, and nausea. Other side effects in children may include diarrhea, cough, fever, and abdominal pain.

Have you had an "Oh, Yes I Can!" moment?

Real patients telling real stories can be inspirational. If you've had an ORENCIA "Oh, Yes I Can!" moment, upload your own experience. You, too, could be an inspiration to others with RA.

ORENCIA® (abatacept) Important Safety Information

Indication and Usage

ORENCIA® (abatacept) is a prescription medicine that reduces signs and symptoms in adults with moderate to severe rheumatoid arthritis (RA), including those who have not been helped enough by other medicines for RA. ORENCIA may prevent further damage to your bones and joints, and may help your ability to perform daily activities. ORENCIA also reduces signs and symptoms in children and adolescents 6 years of age and older with moderate to severe polyarticular juvenile idiopathic arthritis (JIA).

ORENCIA can also make your immune system less able to fight infections, so you may be more likely to get infections or any infection you have may get worse. It is important to tell your doctor if you think you have any infections.

Important Safety Information About ORENCIA® (abatacept)

Before you receive treatment with ORENCIA, a lyophilized powder for intravenous infusion, you should tell your doctor about all your medical conditions, including if you:

• have any kind of infection even if it is small (such as an open cut or sore) or an infection  that is in your whole body (such as the flu).
• have an infection that will not go away or a history of infections that keep coming back.
• have had tuberculosis (TB), a positive skin test for TB, or if you recently have been in contact  with someone who has had TB. If you get any of the symptoms of TB (a dry cough that doesn't go away, weight loss, fever, night sweats), call your doctor right away. Before you start  ORENCIA, your doctor may examine you for TB or perform a skin test.
• have or have had viral hepatitis. Before you use ORENCIA, your doctor may examine you  for hepatitis.
• have a history of chronic obstructive pulmonary (lung) disease (COPD).
• are scheduled to have surgery.
• are allergic to any of the following ingredients in ORENCIA: abatacept, maltose, monobasic  sodium phosphate, or sodium chloride for administration.
• recently received a vaccination or are scheduled for any vaccination. You should not take live  vaccines if you are receiving ORENCIA.
• have diabetes and use a blood glucose monitor to check your sugar levels. The infusion  of ORENCIA contains maltose, a sugar that can give falsely high blood glucose readings  with some monitors on the day you receive your infusion. Your doctor may tell you to use  a different way to monitor your blood sugar levels.
• are pregnant, planning to become pregnant, or are thinking about becoming pregnant.  It is not known if ORENCIA can harm your unborn baby.
• are breast-feeding. You will need to decide to either breast-feed or receive treatment  with ORENCIA, but not both.
• take any other kinds of medicine, including prescription and nonprescription medicines,  vitamins, and herbal supplements.
• are taking other biologic medicines to treat RA or JIA such as: Enbrel® (etanercept),  Humira® (adalimumab), Remicade® (infliximab), Kineret® (anakinra) or Rituxan® (rituximab).  You may have a higher chance of getting a serious infection if you take ORENCIA with  other biologic medicines.

Possible Side Effects of ORENCIA® (abatacept)

ORENCIA can cause serious side effects including:

• Serious infections. Patients receiving ORENCIA have a higher chance of getting  infections including pneumonia, and other infections caused by viruses, bacteria,  or fungi. Call your doctor immediately if you feel sick or get any of the following signs  of infection: fever, feel very tired, cough, feel flu-like, or warm, red or painful skin.
• Allergic reactions. Allergic reactions can happen on the day of treatment or the day after receiving ORENCIA. Tell your doctor or get emergency medical help right away  if you have hives, swollen face, eyelids, lips, tongue, throat, or trouble breathing.
• Cancer (malignancies). Certain kinds of cancer have been reported in patients receiving ORENCIA. It is not known if ORENCIA increases your chance of getting certain kinds  of cancer.
• Vaccinations. You should not receive ORENCIA with certain types of vaccines. ORENCIA may  cause some vaccinations to be less effective.
• Respiratory problems in patients with COPD. You may get certain respiratory problems  more often if you receive ORENCIA and have COPD, including: worsened COPD,  pneumonia, cough, or trouble breathing.

The more common side effects with ORENCIA in both adults and children are headache, upper respiratory tract infection, sore throat, and nausea. Other side effects in children may include diarrhea, cough, fever, and abdominal pain.

Please click here for Patient Information in the Full US Prescribing Information.

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